Scientists
at Purdue used a novel approach to show that a molecule called acrolein is
elevated in blood and urine from mice with MS-like disease and from people with
MS, compared to those without the disease. Acrolein is normally a waste
product, but seems to accumulate in people with neurologic disease, becoming
toxic to nerve cells. They are now testing whether acrolein levels correlate with
disease activity, to determine if this molecule may eventually be used to
identify MS with a simple blood test. Medications targeting acrolein are
already on the market, raising its potential as a therapeutic target for MS.
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